Super ViGest is formulated to provide the specific enzymes needed to digest a balanced diet containing lipids, protein, and carbohydrates. The enzyme blends in Super ViGest will enhance the digestibility of the molecules most commonly found in human diets and will ultimately optimize a more complete and balanced procurement of nutrients needed by the body to sustain health and vitality.*

Optimal digestion is dependent on the presence of effective digestive enzymes. It has been established that stable, ingested enzymes work with endogenous enzymes in maximizing the digestive process1. Super ViGest contains highly active enzymes with a broad range of specificities in order to handle all food preferences.*

1 Prochaska, L.J. and Piekutowski, W.V. “On the synergistic effects of enzymes in food with enzymes in the human body. A literature survey and analytical report.” Med. Hypotheses 1994; 42: 355-362.

Listen to a Conference Call about Super ViGest

Hosted by David Bertrand

featuring DicQie Fuller, Ph.D.

SUPER VIGEST INCLUDES
This digestive formula helps facilitate the digestion of all carbohydrates, since the enzymes in this blend can tolerate the low pH of the gastric juice. It is important to note that no single carbolytic enzyme can adequately hydrolyze the various carbohydrates in human diets. Therefore, Super ViGest is formulated to ensure optimum polysaccharide digestion. Amylase catalyzes the complete digestion of starch in the gastrointestinal tract. Malt diastase attacks starch that is cleaving off (primarily disaccharides). Lactase is for the digestion of lactose (milk sugar) into both glucose and galactose. Invertase breaks down sucrose into both glucose and fructose. Cellulase has been added to this formulation in order to increase the water-binding capacity of the cellulosic fibers in the diet. The binding of water increases stool bulk and decreases bowel transit time. Additionally, the presence of cellulase will increase the ability of cellulose to remove toxins.*

Lipase aids the body in the normal digestion of dietary fats. Incomplete digestion of fats may result in a number of conditions that include nausea, diarrhea, skin ailments, lack of cell membrane integrity, and a reduction of blood-clotting time. The incomplete digestion of fats can also contribute to the coating of food particles that can interfere with the hydrolysis of other food components, such as proteins and carbohydrates. Additionally, the action of this vital lipid-digesting enzyme helps secure the optimum absorption of essential fatty acids. This, in turn, can strengthen the overall health of the body.*

The protease in Super ViGest is active in a wide range of pH’s, ensuring that proper protein digestion will initiate in the stomach. Protease enzymes are necessary for the complete hydrolysis of proteins thus liberating amino acids, the building blocks for every cell in our body including muscle, tissue, blood cells and immune cells. *

Furthermore, proteases taken with meals also alleviate the digestive overload on the stomach and pancreas. Although the stomach secretes pepsin and the pancreas secretes most of the other digestive enzymes (including the proteases trypsin and Chymotrypsin), there are many conditions that lead to inefficiencies in their hydrolytic actions. Thus, it is important to supplement the body with effective, gastrointestinal tract (GI) stable, and functionally active enzymes that help provide essential amino acids to the body.*

L. acidophilus and B. Longum are microorganisms known as “probiotics” that are friendly to the human GI tract. The value of friendly bacteria is well established and includes enhanced digestion, immunity, and pH balance within the digestive tract. Oral supplementation with L. acidophilus can enhance the body’s anti-infective mechanisms of defense2. Research has suggested how stimulation of the production of interleukin-1 alpha and tumor necrosis factor-alpha is one mechanism that shows the beneficial effects of swallowing L. acidophilus. These substances have potent cytocidal and cytostatic effects on tumor cells3. The mechanisms of immune support provided by B. longum have been widely studied in animal models. It has been found that B. longum stimulates the immune system by enhancing the activity of natural killer cells in the spleen of rats4 and by stimulating intestinal IgA production5.*

2 Adler, A.J. & Holub, B.J., “Effect of garlic and fish-oil supple mentation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.” Am J Clin Nutr 1997; 65: 445-50.
3 Nityanand, S., Srivastava, J.S., and Asthana, O.P., “Clinical trials with gugulipid. A new hypolipidaemic agent.” J Assoc Physicians India 1989; 37: 323-8.
4 Lietti A., “Choleretic and cholesterol lowering properties of two artichoke extracts” Fitoterapia 1977; 48: 153-8.
5 Wiseman H., “Dietary influences on membrane function: Importance in protection against oxidative damage and disease” Nutr Biochem 1996; 7: 2-15.

INDICATIONS:*
GALL BLADDER FUNCTION - The normal digestion of dietary fats is accomplished by lipases with the assistance of bile, which is produced by the liver and supplied through the gall bladder and whose function is to bring ingested fats into emulsion in order to facilitate the work of the lipases. The lipase in Super ViGest provides the liver and gall bladder with additional assistance. This support can help the body compensate for impaired bile production due to gall bladder stress or due to gall bladder removal.*
MALABSORPTION - The absorption of nutrients from the digestive tract depends upon the degradation of proteins into amino acids and carbohydrates into simple sugars. The absorption of nutrients derived from fats is somewhat complicated and requires both emulsification from bile and degradation from lipases. Malabsorption of nutrients may therefore arise as a result of incomplete digestion. The broad spectrum of stable and functional digestive enzymes in Super ViGest addresses this concern.*
FOOD ALLERGIES - Food allergies may result from undegraded food macro-molecules leaking into the blood. The immune system mounts a response to these “invaders” and becomes primed to strongly respond to subsequent presentations of these antigens. However, thorough degradation of the ingested food macro-molecules into their simplest monomers will destroy any antigenicity and will reduce the re-occurence of food allergy.*

ADDITIONAL READING:
Beazell, J.J. Ph.D., MD. “A re-examination of the role of the stomach in the digestion of carbohydrate and protein.” American Journal of Physiology 132: 42-50 (1941)
Bashaw, Ed. Digestion, Assimilation, Elimination and You.
Godfrey, Tony; Reichelt, Jon. Industrial Enzymology: The Application of enzymes in Industry. New York: The Nature Press, 1983
Graham, David Y. “Ins and outs of pancreatic enzymes and adjuvant therapies.” Journal of Pediatric Gastroenterology and Nutrition 3:S120-26 (1984)
Grossman, M.I.; Greengard, H.; Ivy, A.C. “The effect of dietary composition on pancreatic enzymes.” American Journal of Physiology 139:676-82 (1942)
Grossman, M.I.; Greengard, H.; Ivy, A.C. “On the mechanism of the adaptation of pancreatic enzymes to dietary composition.” American Journal of Physiology 141:38-41 (1944)
Howell, Edward, MD. Food Enzymes for Health and Longevity. Woodstock Valley, CN: Omangod Press, 1980
Howell, Edward, MD. Enzyme Nutrition: The Food Enzyme Concept. Wayne, NJ: Avery Publishing Group, Inc. 1985
Ivy, A.C.; Schmidt, C.R.; Beazell, J.M. “On the effectiveness of malt amylase on the gastric digestion of starches.” The Journal of Nutrition 12: 59-83 (1936)
Dutta, S.; Rubin, J.; Harvey, J. “Gastroenterology” 84: 476-82. 1983
Fuller, Dr. DicQie. The Healing Power of Enzymes. Forbes Publishing Co, New York, 1998
Howell, Edward. The Status of Food Enzymes in Digestion and Metabolism. Avery Publications, 1946
Wolf & Ransbager. Enzyme Therapy. Regent House, 1972
Smyth, R.D.; Brennan, R.; Martin, G.J. “Systemic biochemical changes following oral administration of the proteolytic enzyme bromelain.” Archives of International Pharmacodynamics 136:230-6, 1962
Meagher, M.M., and Reilly, P.J. “Kinetics of the hydrolysis of Di-and Trisaccharides by Aspergillus Niger.”

More Information:

Where Do Vitamark's Enzymes Come From?
Should Children Take Enzymes?
Frequently Asked Question About Protein Digesting Enzymes
More Questions About Enzymes and Probiotics

Where Do Vitamark's Enzymes Come From?

Vitamark's enzymes are derived from the fermentation of non-toxogenic strains of aspergillus-niger and Aspergilus oryzae. These organisms have been studies extensively to establish their safe use. For more information on their safety read the report that follows:

The Safety of Enzymes Derived from Aspergillus

The Production of Mycotoxins by Some Species of Aspergillus
Numerous studies have shown that certain species of the Aspergillus fungus can pose a health threat. These species of Aspergillus produce one or more natural substances that are extremely toxic to other living organisms.4,7 Toxigenic strains of Aspergillus flavus and Aspergillus parasiticus produce the closely related group of mycotoxins called “aflatoxins.”9 These toxins have been the subject of intense study as they exhibit potent hepatotoxicity, mutagenicity, teratogenicity, carcinogenicity, and immunosuppression in laboratory animals.4 Human cases of aflatoxin poisoning have been associated with the consumption of contaminated foods. In these instances, living Aspergillus fungus was growing or had grown upon the food and was responsible for the presence of aflatoxins.3 Considering the serious health risks associated with these aflatoxins, it is understandable that there is some concern over the possible presence of mycotoxins in enzymes derived from Aspergillus.

The Selection of “Safe” Organisms in the Fermentation Process
Before a fungal organism is used in fermentation, the specific strain is extensively screened to determine if the organism is capable of producing mycotoxins under the conditions of fermentation. Only those organisms that do not produce any toxins are selected for use in the fermentation process.5,11,14 Even after an organism is determined to be “safe” and is used in fermentation, every second generation is again checked to verify that mutations have not occurred which might enable the organism to produce mycotoxins. Enzymes derived from Aspergillus fermentation were first used in food production at the turn of the century.5,14 Since their introduction, there has never been a documented case of illness from mycotoxins associated with fermented enzymes,5 which is testament to the effectiveness of the screening process employed by the enzyme manufacturing industry.

Vitamark International only uses fungal enzymes derived from the fermentation of non-toxigenic strains of Aspergillus-niger and Aspergillus oryzae. These organisms have been studied extensively by the food and pharmaceutical industries to establish their safe use in the production of amino acids, enzymes, antibiotics and other beneficial compounds.1,7,15

Enzymes are Isolated Proteins, not Living Organisms
Once fermentation by the Aspergillus organism is complete, the enzymes are extracted by a complex process that isolates protein compounds from the surrounding material. No living Aspergillus cells remain in the isolated enzyme after the extraction process is complete.5,11,14 Mycotoxins are not protein-based substances;8 therefore, in the extremely unlikely event that mycotoxins were produced during fermentation, they would not be extracted with the enzymes. Instead, any mycotoxins present would remain in the discarded portion of the fermentation. Even so, the final enzyme product is routinely checked for the presence of mycotoxins and aflatoxins.13

Infections Associated with Aspergillus
Aspergillus, like any other fungus, can act as opportunistic pathogens; however, the relative rarity of Aspergillus infections indicates the low degree of innate virulence of these organisms. Infectious diseases associated with Aspergillus involve growth of fungal mycelia within body tissue, most commonly within the pulmonary system.3 In order for mycelial colonization to occur, the Aspergillus must be introduced to the body in a living form. Enzymes derived from the fermentation of Aspergillus are purified compounds which do not contain any living Aspergillus cells and therefore cannot initiate infection or colonization.11,14 No cases of Aspergillus infections have ever been documented in association with the consumption of purified fermented fungal enzymes.

Allergic Reactions to Aspergillus
Allergic responses to Aspergillus organisms and the products of their fermentation do occur, although their occurrence is largely isolated to regular air-borne “dust” exposure by workers in the food industry.2,8,10 If an allergic reaction is to occur, it is generally the protein faction of a substance that will illicit such a reaction.6 Although enzymes derived from Aspergillus fermentation are free of any living Aspergillus cells, the fact remains that these enzymes are a purified protein faction of the Aspergillus organism. If you have any questions regarding the use of these enzyme products, please contact your health care professional or Questions@Vitamark.com.

References:
1Barbesgaard, P.; Heldt-Hansen, H.P.; Diderichsen, B. “On the safety of Aspergillus oryzae: a review.” Appl. Microbiol. Biotechnol. 36(5): 569-72 (1992).
2Baur, X.; Chen, Z.; Sander, I. “Isolation and denomination of an important allergen in baking additives: a-amylase from Aspergillus oryzae (Asp o II).” Clinical and Experimental Allergy 24: 465-70 (1994).
3Dixon, D.M.; Walsh, T.J. “Human Pathogenesis” in Aspergillus: Biology and Industrial Applications edited by J.W. Bennet and M.A. Klich. (Boston: Butterworth-Heinemann, 1992) pp 249-265.
4Dvorackova, I. Aflatoxins and Human Health. (Boca Raton: CRC Press, 1990).
5Godfrey, T.; Reichelt, J. Industrial Enzymology: The Application of Enzymes in Industry. (New York: The Nature Press, 1983).
6Guyton, A.C. Textbook of Medical Physiology, 8th ed. (Philadelphia: W.B. Saunders Company, 1991).
7Linz, J.E.; Pestka, J.J. “Mycotoxins: Molecular Strategies for Control” in Aspergillus: Biology and Industrial Applications edited by J.W. Bennet and M.A. Klich. (Boston: Butterworth-Heinemann, 1992) pp 217-229.
8Losada, E: Hinojosa, M.; Quirce, S.; Sanchez-Cano, M.; Moneo, I. “Occupational asthma caused by alpha-amylase inhalation: clinical and immunologic findings and bronchial response patterns.” J. Allergy Clin. Immunol. 89(1): 118-25 (1992).
9Pier, A.C.; Richard, J.L. “Mycoses and Mycotoxicoses of Animals Caused by Aspergilli” in Aspergillus: Biology and Industrial Applications edited by J.W. Bennet and M.A. Klich. (Boston: Butterworth-Heinemann, 1992) pp 233-247.
10Quirce, S.; Cuevas, M.; Diez-Gomez, M.; Fernandez-Rivas, M.; Hinojosa, M.; Gonzalez, R.; Losada, E. “Respiratory allergy to Aspergillus-derived enzymes in bakers’ asthma.” J. Allergy Clin. Immunol. 90(6): 970-8 (1992).
11Reed, G. Enzymes in Food Processing, 2nd ed. (New York: Academic Press, 1975).
12Richard, J.; Cole, R. Mycotoxins: Economic and Health Risks Report no. 116. (Ames, IA: Council for Agricultural Sciences and Technology Task Force Report, 1989).
13Schechtman, M.G. “United States Government Regulations Affectiong Aspergilli and Their Products” in Aspergillus: Biology and Industrial Applications edited by J.W. Bennet and M.A. Klich. (Boston: Butterworth-Heinemann, 1992) pp 233-247.
14Schwimmer, S. Source Book of Food Enzymology. (Westport, CT: The AVI Publishing Company, Inc., 1981).
15Wei, D.L.; Johg, S.C. “Production of aflatoxins by strains of the Aspergillus flavus group maintained in ATCC.” Mycopathologia 93(1): 19-24 (1986).

Should Children Take Enzymes?
from Jana Mitcham

If your general philosophy towards health is to prevent and be proactive, you should definitely give your child enzymes. In order to make sure your child gets proper nutrient acquisition, you want to promote optimal digestion, a healthy immune system, and a healthy GI tract with proper elimination.*

Can children take enzymes?
Yes, absolutely. You can give digestive enzymes to infants, toddlers, and young children. For toddlers and young children, Vitamark recommends the basic protocol of Super Vi-Gest, Revitalgen, and Probiotic. If children can't swallow the capsule they can be pulled apart easily and mixed with water or juice. (For young children who can't follow the Suggested Use, mix it by adding the liquid a little at a time, when powder is assimilated and mixture is liquid (may be as little as 1 cc of liquid used) give to child by spoon, oral syringe or medicine dropper.

How do I give the digestive enzymes to a baby?
When breast-feeding, we first suggest that the mother take the basic enzyme protocol a digestive formula such as Super Vi-Gest, a proteolytic formula like Revitalgen and our Probiotic to ensure that her digestion is optimal. Many times this calms the baby's digestive system as well. However, if the baby's digestion still needs assistance, you can easily and safely administer the enzymes. Simply pull apart the Super Vi-Gest capsule, mix the powder in a small amount of tepid water or room temperature juice – mix approximately 1cc and administer as suggested above. Give it to the baby before the normal feeding. At times, it may be difficult to give the enzymes prior to feeding. If this is the case, you may give the enzymes to the baby after feeding.

If the baby is being formula-fed, the enzymes should be mixed with 1cc of tepid water or room temperature juice and given just before feeding, as described above. Note: Do not mix the enzymes with formula in the bottle, as it will begin digesting the formula immediately. If it is difficult to give the enzymes prior to feeding, the enzymes may be given after feeding.

How much do you recommend and how often?
Our rule of thumb is to address the need. This means the dose you give a toddler may be the same as the dose you give an adult, if their need is the same.

A safe and effective protocol for children is:

1-3 Super Vi-Gest with every meal
2 Revitalgen 3 times daily between meals
3 Probiotic at bedtime or 1 in the morning and 2 at bedtime

For infants:

1-2 Super Vi-Gest with each feeding
1 Probiotic in the AM and 1-2 Probiotic in the PM
Revitalgen may be added as needed between feedings and/or with feedings depending on circumstances

A frequently asked question about enzymes that digest proteins
(proteases like found in Revitalgen and Super Vi-Gest) is:

If protease digests proteins, how does it distinguish between the good and bad bacteria, or even self and non-self? And, how is it possible to take proteases with probiotics without digesting the probiotics?

Proteases(like those found in Revitalgen and Super Vi-Gest), supplemental or endogenous, only break down compromised proteins. The protein may be “of self” (muscle, blood, beneficial bacteria) or foreign (toxins, unfriendly bacteria,), and if it is intact, the protease will leave it alone. Note – this is why it is ok to take Protease and Probiotic at the same time.

Proteases (supplement or endogenous) will breakdown any protein if that protein is unhealthy (and temperature, pH and moisture conditions are right).

Our immune cells (supported and modulated by proteases) are what target the foreign invaders. It is our immune cells that compromise the bad proteins and then the protease can assist by breaking it down further and helping remove from the system.

With regard to the GI tract and the balance of good and bad bacteria there, what we eat and how well we digest it, is crucial. Undigested carbs ferment, proteins putrify and fats turn rancid and unfortunately bad bacteria thrive on this unhealthy environment. Furthermore, an unhealthy diet and poor digestion can lead to pH imbalances throughout the body, which can also allow for opportunistic organisms to thrive.

So, a healthy diet(that includes systemic enzymes like those found in Revitalgen) and optimal digestion (often requires additional digestive enzymes like found in Super Vi-Gest)coupled with balanced gut flora(Probiotics contributes to this balance) is key!

More Questions About Enzymes and Probiotics?

Does Super ViGest contain Milk products or can someone that can`t tolerate milk products (lactose intolerant) take SuperViGest?

a. This formulation contains Lactase, the enzyme needed for digesting lactose. There are no milk products in this formula and yes it will help w/ lactose intolerance. However, my clinical experience has been that those patients w/ lactose intolerance still need to avoid those foods when possible.

b. People also sometimes wonder if the lactobacillus (an ingredient in Probiotic also)contains milk. No it does not.

If a person sometimes has a problem tolerating meat..Can you use Super ViGest anyway? Do Revitalgen and Super ViGest include protein?

a. The Revitalgen and Super ViGest formulas contain a protease blend that helps digest proteins (meat). They should be able to tolerate small servings of meat if taking Super ViGest.

b. If they feel they still need additional support digesting meat, they can take an additional Revitalgen with the meal. This formula is especially high in proteases.

c. Neither Revitalgen or Super ViGest contain protein.

A few of our affiliates say that they get gases in their stomach when taking Super ViGest. Is this a side effect that you have heard about before? For myself (and the dogs) Super ViGest is the absolute best thing that has happend, and we never get gases from it.. Only wonderful benefits like less cravings and no stomach catarrh.

a. This does occur occasionally. Try taking the Probiotic with the meal along w/ Super Vigest as this often helps.

b. Check into the diet. Sometimes it is the food they are eating. Now that they are digesting better, the food choice may be the problem. Taking 3 Super ViGest might be helpful with high gas producing foods.